Trazodone is a serotonin modulator that has a number of functions that increase the amount of available serotonin in the central nervous system and other areas of the body. It primarily acts as a serotonin reuptake inhibitor and serotonin antagonist.

Trazodone, which goes by the number of different brand names such as Desyrel, was initially designed to be used in the treatment of clinical depression. The drug has significant sedating effects, and it is more often used as a sleep aid for people that have various psychological disorders, including depression, anxiety disorders, fibromyalgia, and psychological disorders that include restlessness and irritability.

Trazodone as a Drug of Abuse


Certain classes of drugs have higher potentials for abuse and the development of physical dependence than others. Antidepressant medications, such as trazodone, have a relatively low potential for abuse and the development of physical dependence compared to drugs like narcotic medications (e.g., morphine, OxyContin, Vicodin, etc.), benzodiazepines (e.g., Valium, Xanax, Klonopin, etc.), stimulant medications, and alcohol. For many years, many prominent individuals in the mental health profession, medical profession, and pharmaceutical industry maintained that antidepressant medications were not potential drugs of abuse and did not have the potential to cause physical dependence. However, this position has been reversed.

According to professional sources, such as the American Psychiatric Association, the abuse of any drug is typically defined as any type of use that is outside the parameters of the drug’s intended medicinal usage. Individuals taking trazodone without a prescription, using it to enhance the effects of other drugs of abuse, or taking it for any specific psychoactive properties, such as sedation, without being prescribed the drug are abusing the drug.

It is currently recognized that antidepressant medications can be potential drugs of abuse. Nonetheless, the abuse of antidepressant medications is relatively rare and most often occurs in conjunction with abuse of other types of drugs, such as narcotic medications, benzodiazepines, stimulants, etc. The formal acceptance of the notion that antidepressant medications could be drugs of abuse was supported in 1994 by two case studies reported in the Mayo Clinic Proceedings that documented the abuse of the antidepressant Prozac and a case of co-abuse of trazodone.

A later study reported in the journal Psychopharmacology compared the abuse potential of Ambien, Halcion, and trazodone. The abuse potential of these drugs was rated by former drug abusers themselves as well as objective measures. The findings indicated that trazodone does have some potential for abuse; however, its potential for abuse was far less serious as the potential for abuse of Ambien and Halcion, medications that are also used to induce sleep.

Individuals with substance use disorders may resort to abusing any type of drug or medication in order to achieve some form of psychoactive effects. Since trazodone does produce mild sedation, and this is often interpreted as a mild euphoria in some individuals, it is a potential drug of abuse. Individuals will often grind up the drug and snort it, which is a sure sign of drug abuse since this is not within the confines of its prescribed use.

It has also been recognized that antidepressant medications such as trazodone have the potential for the development of a mild syndrome of physical dependence if they are used for periods of more than six weeks. This syndrome of physical dependence that occurs as a result of antidepressant medications has been termed antidepressant discontinuation syndrome (ADS; more information about this syndrome will be presented below).

Who Abuses Antidepressants like Trazodone?


According to a number of sources, including the National Institute of Health, individuals who abuse prescription medications such as trazodone are not likely to be legitimately prescribed the medication under the supervision of their physician. They are more likely to abuse the medication as a secondary drug of abuse in combination with other drugs. These people typically have histories of substance use disorders to drugs that are not in the antidepressant classification.

Overall, people who use prescription medications for nonmedicinal purposes are more likely to abuse antidepressant medications like trazodone. In addition, those who use antidepressant medications for periods greater than 6-8 weeks may develop a mild physical dependence on the drugs. Some individuals may have difficulty stopping their use of the medication due to the withdrawal symptoms associated with physical dependence; however, these withdrawal symptoms are very mild and reported to be equivalent to a mild case of influenza.

Individuals who develop physical dependence on a medication as a result of prolonged use for medicinal purposes and have used the drug under the supervision of a physician are not considered to have substance use disorders. A substance use disorder by definition indicates that the individual is engaging in nonmedicinal use of a drug or medication, and this abuse results in negative consequences for the individual.

Antidepressant Discontinuation Syndrome (ADS)


A syndrome of physical dependence includes both the symptoms of tolerance (needing more of the substance to produce effects that were once produced at lower doses) and withdrawal (a series of negative effects that occur when an individual stops using a drug or cuts down on the dosage). ADS denotes the withdrawal portion of the physical dependence syndrome.

Many individuals will develop a low-level tolerance to antidepressant medications after they take them for extended periods and may need to have their dosage adjusted. In addition, a number of individuals who use antidepressant medications for periods of longer than 6-8 weeks may develop ADS. The symptoms of ADS are quite varied and may include:

  • Mood swings that resemble the symptoms of clinical depression
  • Anxiety
  • Somatic symptoms, such as insomnia, dizziness, mild headache, fatigue, and other flu-like symptoms, such as muscle aches, nausea, sweating, and a low-grade fever
  • Vivid dreams or nightmares
  • Hallucinations, in rare cases

The duration of ADS appears to be relatively short with a median of about eight days, though it can range from three days to several weeks. The symptoms are generally considered to be mild. Although ADS appears to be associated with nearly any type of antidepressant medication, medications that directly affect the neurotransmitter serotonin are more likely to produce ADS.

The most common strategy to avoid the symptoms of ADS is to discontinue trazodone under the supervision of a physician. Physicians typically employ tapering strategies where successively lower doses of the drug are administered until the individual is weaned off the medication with minimal effects.

Some individuals who may be emotionally unstable may be at risk for self-harm due to the effects of ADS. This can occur as a result of an accident, poor judgment, or even rare cases of individuals becoming distraught and suicidal. It is also very difficult to predict who will develop rare symptoms, such as vivid nightmares or hallucinations. For these reasons, it is suggested that anyone who is using or abusing an antidepressant medication and wishes to discontinue use of the medication do so under the supervision of a physician.

Indicators of Abuse


Signs that an individual may have a substance use disorder that involves trazodone include: 

  • A person does not have a prescription but uses trazodone on a regular basis
  • A person with a prescription for trazodone attempts to get more than they are prescribed to use (e.g., via buying it illegally, stealing it, or trying to get different physicians to write prescriptions for the drug)
  • Taking trazodone in ways the drug is not intended to be taken, such as grinding it up and snorting it
  • Using trazodone in conjunction with other drugs of abuse
  • Continuing to use trazodone despite negative consequences as a result of its use
  • Use of trazodone affects one’s health or psychological wellbeing

Treatment for Trazodone Addiction


As mentioned above, the most likely scenario that occurs when individuals are abusing trazodone is that they are abusing multiple drugs. When individuals develop substance use disorders to multiple substances, this complicates treatment. A good number of these individuals will have co-occurring psychological disorders in addition to their polysubstance abuse. These individuals will require a comprehensive psychological assessment and physical examination to determine the extent of their substance abuse, any other psychological issues that co-occur with the substance abuse, and any physical ailments or ill effects associated with these conditions.

After an assessment, a withdrawal management program is advised to assist the individual in discontinuing all drugs of abuse. An integrated treatment approach that emphasizes a multidisciplinary team approach to care should be employed. This will include physicians, psychologists, counselors, social workers, and other mental health workers to address the specific issues involved. A long-term aftercare program is essential; this program should be designed to help the individual adjust to life in recovery and lower the potential for relapse.