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Yes, mixing the controlled substance lorazepam (also known as Ativan) with alcohol is extremely dangerous and can be deadly. Whether used together inadvertently or for recreational purposes, the interaction of a benzodiazepine such as lorazepam—also known as Ativan—with alcohol presents a significant risk.1
For people who abuse drugs or alcohol, there is often a point at which experimentation with polydrug use – or using more than one drug at a time – becomes part of the picture. One of the most popular substances to combine with other drugs is alcohol.It’s relatively easy to get, and it can easily enhance or otherwise affect the experience of the other substance, such as lorazepam. However, polydrug use can be even more dangerous than using single drugs individually—especially when it comes to combining other sedative type drugs with alcohol.
Lorazepam is commonly prescribed under the trade name Ativan. Ativan a benzodiazepine sedative and anti-anxiety drug. Lorazepam has several approved and off-label uses, including:2
As with many other benzodiazepines, lorazepam can become addictive. Because of the manner in which it influences certain types of brain chemistry, it may be associated with reinforcing, euphoric effects. Especially when misused in doses that exceed prescription guidelines, lorazepam can lead to a rapidly mounting tolerance, dependence, and eventually addiction.
Most people are familiar with alcohol’s effects. Alcohol has some sedative effects similar to benzos. Depending on your frequency and amount of alcohol consumption, you may be at risk of several adverse mental and physical health effects described by the National Institute on Alcohol Abuse and Alcoholism. These may include:3
Some of these effects parallel those experienced when using lorazepam. In fact, it is for this reason, among others, that mixing Ativan and alcohol can be so dangerous.
The effects of sedatives like lorazepam on the body include certain cognitive deficits and slowing of physiological processes, including vital ones like breathing and heart rate. Mixing alcohol with a sedative like lorazepam (Ativan) presents a higher risk of dangerous effects by possibly intensifying the effects of each substance, resulting in a further slowdown of physical and mental capabilities. The combination of lorazepam and alcohol is much more likely to result in symptoms of overdose than the use of either substance alone, and it is a common combination found in emergency room overdose cases.4 This type of interaction is described in an article from American Family Physician.
When the effects of lorazepam and alcohol are amplified, the individual may begin to have serious physiological issues with the systems involved. For example, breathing can slow to the degree that the person becomes unconscious; breathing can even stop, leading to coma or death.1
Other potentially dangerous effects of combining lorazepam and alcohol include:1,4
Any signs or symptoms of overdose could indicate the need for immediate medical help. When high doses of lorazepam are combined with large quantities of alcohol, an individual risks severe physical injury or even death.
Even if an overdose is not experienced, using lorazepam with alcohol can result in deteriorating mental or physical health over time. Long-term issues that may develop in association with chronic lorazepam or alcohol abuse can include:
These risks may arise when using either lorazepam or alcohol alone at high doses for a long time.1,5 However, using Ativan and alcohol together increases the chances of developing these issues and of experiencing an extreme event, such as overdose, in the future.1
Signs that an individual is abusing alcohol with lorazepam may include:1
Again, these combined effects may be similar to those experienced after using large amounts of either drug on its own. Other signs of polysubstance use involving both alcohol and prescription drugs might include:6
When a person is abusing both substances at the same time, they may be at higher risk of severe intoxication and overdose, as described above and in a Treatment Improvement Protocol from the Substance Abuse and Mental Health Services Administration.7 It is important to seek treatment for substance use disorders involving multiple substances to pre-empt such dangerous and potentially-devastating eventualities.
Recognizing that a person is abusing Ativan and alcohol is only the first step. The next is to find a reliable, research-based treatment program that is experienced in dealing with polydrug abuse.
As described in the Treatment Improvement Protocol, abuse of more than one drug can make it highly difficult to stop use of each individual substance.7
Treatment professionals who are trained, certified, and experienced in dealing with abuse of multiple substances can develop a personalized plan that can be more likely to result in a positive treatment outcome.
Finding the right recovery program can provide the best chance for the individual to undergo medical detox and safe, comfortable withdrawal management, appropriate treatment, and ongoing aftercare planning for sustained recovery from combined abuse of lorazepam and alcohol.8 With proper treatment, the individual is more likely to achieve and maintain recovery for the foreseeable future.