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Facts about Naloxone

Naloxone is an opioid antagonist, approved by the Food and Drug Administration (FDA) to treat opioid overdoses. By blocking opioid receptors, naloxone prevents opioids like heroin, morphine, fentanyl, oxycodone, and hydrocodone from binding to those receptors; during an overdose, naloxone kicks opioids off these receptors and temporarily takes their place.

An opioid overdose can occur for several reasons, including:

  • A person taking prescription painkillers for pain management accidentally takes too much.
  • The individual struggles with substance abuse and takes too much illicit opioid.
  • The person struggles with polydrug abuse and mixes opioids with benzodiazepines (e.g., Valium, Klonopin, Xanax, etc.) or alcohol.

How Naloxone Is Used

Symptoms of a naloxone allergy include:

  • Itching, especially around injection site
  • Rash or hives
  • Trouble breathing
  • Facial swelling, or swelling of the lips, tongue, or throat

The drug is prescribed in several forms, including an intranasal spray that has become popular in recent years as a straightforward way for people without medical training to administer naloxone. It can also be injected intravenously or intramuscularly. The most common brand name for naloxone is Narcan.

This opioid antagonist is also part of the withdrawal medication Suboxone. The main ingredient is buprenorphine, a partial opioid agonist, which binds to opioid receptors for a long time and eases withdrawal symptoms in people working to end their addiction to opioids. It does not induce a high in people who have a tolerance for opioid drugs already. Naloxone is added to Suboxone to prevent abuse of the drug to get high; when taken orally, Suboxone reduces withdrawal symptoms, but when snorted, crushed, injected, or otherwise abused, naloxone hits the brain first, preventing buprenorphine from binding to the opioid receptors, which can lead to withdrawal symptoms.

Naloxone does not have any effects unless the individual is allergic to the drug. It is not addictive, and it does not create euphoria. This means it is among the safest drugs available.

Naloxone to Reverse Opioid Overdoses

It is very important to note that naloxone is not a substitute for emergency medical treatment. It can be administered to temporarily reverse an opioid overdose, but it does not stop the overdose completely. Naloxone’s half-life is much shorter than opioid drugs’ half-lives, so the overdose will begin again once naloxone is processed out of the body. Naloxone only lasts in the body for 20-90 minutes, depending on the size of the dose. When a person is overdosing on opioids, call 911 and administer naloxone if it is available. Emergency medical treatment gives the individual the best chance of surviving the overdose.
Symptoms of an opioid overdose include:

  • Excessive sleepiness or falling unconscious
  • Depressed, shallow, or irregular breathing
  • Changes to the pulse
  • Small or pinpoint pupils
  • Gray or clammy skin
  • Bluish tint to skin around the lips, tip of nose, or fingers

For years, first responders and medical professionals were the only people authorized to use naloxone. Now, however, laws are beginning to change. The opioid abuse epidemic kills 91 Americans every day from overdoses, and over 1,000 are hospitalized due to an overdose, according to the Centers for Disease Control and Prevention (CDC). Development of Narcan and Evzio – a nasal spray and an auto-injectable, respectively – allows the public, without medical training, to safely administer a specific dose of naloxone to a person suffering from an opioid overdose.

National Laws and Changing Attitudes toward Naloxone

Doctors and harm reduction groups have used naloxone successfully to reverse overdoses since 1996. The CDC reports that at least 26,000 overdoses have been reversed, and the individuals survived, thanks to naloxone administration. Most states allow doctors to prescribe naloxone to those who use prescription opioids, but as the opioid abuse epidemic continues to take many lives, several states and drug store chains are making naloxone available over the counter. This means that people who may be struggling with heroin addiction, or another kind of opioid addiction, can purchase packages of naloxone, no questions asked.

Good Samaritan laws in just over half the states in the US and the District of Columbia protect those who call emergency responders if they witness an opioid overdose. This is because many times, the person who witnesses the overdose is also someone struggling with opioid addiction, so they may have purchased or helped administer the opioid that led to the overdose. Good Samaritan laws protect these people from prosecution for possessing or taking drugs.