Drugs and Hallucinogen Persisting Perception Disorder


Hallucinogen persisting perception disorder (HPPD) is a condition that causes an individual to re-experience sensory disturbances that can mimic those brought on during prior drug use.1,2 HPPD occurs among users of hallucinogenic recreational drugs, most commonly lysergic acid diethylamide (LSD) but may also be triggered by other substances, such as alcohol, marijuana, ecstasy/molly (MDMA) and phencyclidine (PCP).1-4

Sometimes referred to as an “acid flashback,” in order to be diagnosed officially with HPPD, according to the American Psychological Association’s Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), the disturbances must be prominent or chronic enough that they cause distress or functional impairment.1 In persons with HPPD, flashbacks may persist for weeks, months, or even years.1

Hallucinogens are drugs that alter a user’s perception of the world around them.2,3 While intoxicated, people often experience intense emotional swings and report seeing images, hearing sounds, and feeling sensations that seem real but aren’t.3

Some hallucinogens occur naturally, and many of them have been and some are still used today in religious ceremonies.2 LSD, a synthetic hallucinogen was popular in the 1950s and 1960s as an experimental psychedelic that was used both recreationally and in psychiatric research.2

According to the 2018 National Survey on Drug Use and Health, more than 15% of people ages 12 and older had used a hallucinogen at least once in their lifetime.5 About 2/3 of those people reported using LSD.5

Prevalence and Symptoms of HPPD

Hallucinogen persisting perception disorder is uncommon. Even among the population of hallucinogenic drug users, the prevalence estimate is approximately 4.2%.1

There isn’t much known about HPPD given the limited amount of research done on the rare condition.1,4 The risk of experiencing HPPD does not appear to be linked to the frequency of exposure to hallucinogens or other drugs.1 It is more often diagnosed in individuals with a previous history of mental problems or substance abuse, but it can occur in people who have taken a hallucinogenic drug only once.4

Symptoms of HPPD appear when a person is no longer intoxicated and include:1,2,4

  • Abnormal visual perceptions of geometric shapes.
  • False perceptions of movement in peripheral vision.
  • Flashes of color.
  • Objects with halos.
  • Visual hallucinations where moving objects have trails or trailing colors.
  • Perception of flickering light.
  • Enhanced intensity of color.

People with HPPD are aware that what they are seeing is not real.1,2,8 Symptoms may be mild and benign at times, and the afflicted individual might even enjoy the “free trip,” as it resembles a psychedelic experience without ingesting a hallucinogenic drug.4 It may also develop into a condition that’s long-term, pervasive and which may be slow or impossible to reverse.4

A person diagnosed with HPPD experiences social or occupational impairment as a result of the recurring hallucinations.1 Case reports suggest impairments can get so bad that individuals may also meet the criteria for depression, anxiety or panic disorders, or even schizophrenia.6-8

Sometimes, despite past drug use, symptoms of HPPD are caused by a medical condition or may be better explained by another mental disorder, such as schizophrenia.1,6-8 Doctors may rule out these possibilities before settling on HPPD as the cause of hallucinations.1,6-8

Visual and auditory disturbances that are experienced only upon waking from sleep, called “hypnogogic hallucinations,” are excluded from a diagnosis of HPPD.1 About 12.5% of people experience hypnogogic hallucinations, and they are associated in people with insomnia, excessive daytime sleepiness, and other mental disorders.9

Treatment Options

Symptoms of HPPD may simply dissipate on their own over time. For others, it is a long-lasting and seemingly irreversible condition.1,2,6-8

There’s no specific course of treatment for those experiencing HPPD.2,4,7 Abstinence from hallucinogenic substances is critical, and a variety of pharmacological approaches have been successful in the cases documented in peer-reviewed medical literature.2,7 Drugs used successfully in these cases of HPPD have included benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), anticonvulsants and neuroleptics.2,7 In some instances, however, these and other drugs—particularly SSRIs and antipsychotics—have also been documented as worsening symptoms.2,6

Behavioral therapy, either one-on-one or group therapy, may also be helpful, especially if HPPD has been a source of marked anxiety and if stress exacerbates symptoms and results in social isolation.7

References

  1. Diagnostic and statistical manual of mental disorders: DSM-5. (5th ed.). (2013). Washington, D.C.: American Psychiatric Association.
  2. Miller, S. C., Fiellin, D. A., Rosenthal, R. N., & Saitz, R. (2019). The ASAM Principles of Addiction Medicine, Sixth Edition. Philadelphia: Wolters Kluwer.
  3. National Institute on Drug Abuse. (2015.) What Are Hallucinogens and Dissociative Drugs?
  4. Martinotti, G., Santacroce, R., Pettorruso, M., Montemitro, C., Spano, M. C., Lorusso, M., di Giannantonio, M., & Lerner, A. G. (2018). Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives. Brain Sciences, 8(3), 47.
  5. Center for Behavioral Health Statistics and Quality. (2019). Results from the 2018 National Survey on Drug Use and Health: Detailed Tables. Substance Abuse and Mental Health Services Administration, Rockville, MD.
  6. Hermle, L., Simon, M., Ruchsow, M., & Geppert, M. (2012). Hallucinogen-persisting perception disorder. Therapeutic Advances in Psychopharmacology, 2(5), 199–205.
  7. Kurtom, M., Henning, A., & Espiridion, E. D. (2019). Hallucinogen-persisting Perception Disorder in a 21-year-old Man. Cureus, 11(2), e4077.
  8. Noushad, F., Al Hillawi, Q., Siram, V., and Arif, M. (2015). 25 years of Hallucinogen Persisting Perception Disorder- A diagnostic challenge. BJMP, 8(1):a805.
  9. Teeple, R. C., Caplan, J. P., & Stern, T. A. (2009). Visual hallucinations: Differential diagnosis and treatment. Primary Care Companion to the Journal of Clinical Psychiatry, 11(1), 26–32.


About The Contributor

Ryan Kelley, NREMT
Ryan Kelley, NREMT

Medical Editor, American Addiction Centers

Ryan Kelley is a nationally registered Emergency Medical Technician and the former managing editor of the Journal of Emergency Medical Services (JEMS). During his time at JEMS, Ryan developed Mobile Integrated Healthcare in Action, a series... Read More


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