10 clear pill cases filled with 2-CE on a black background

The drug 2-CE (2,5-Dimethoxy-4-ethylphenethylamine) is a synthetic psychedelic drug that is classified as a phenethylamine. It was first synthesized and developed in the 1970s. Alexander Shulgin, who developed it, rated it is one of the major psychedelic compounds he had used.

Its effects appear to be highly unpredictable depending on the dose, and it is classified as a Schedule I controlled substance by the United States Drug Enforcement Administration (DEA). This classification indicates that the drug has no known medicinal uses, is considered to be extremely dangerous, and is a serious potential drug of abuse that may result in the development of psychological or physical dependence in people who use it. There appears to be limited information regarding toxic levels of the drug and whether or not the drug results in the development of tolerance and withdrawal symptoms. The DEA suggests that tolerance develops very rapidly to the drug, but a formal withdrawal syndrome is not identified.

Psychedelic drugs produce distortions in perception, such that individuals often perceive things that are not really there. Most often, these drugs produce visual hallucinations and certain bodily sensations, such as dissociation or feeling detached from oneself or reality. The effects of 2-CE are reported to consist of numerous idiosyncratic experiences of dissociation and significant manifestations of visual and auditory hallucinations. The drug is often purchased online, and these substances can be highly unstable and dangerous, especially when purchased from such sources.

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How Long Does the Drug Stay in the System?

The length of time that any drug remains in a person’s system can be quite variable. In large part, the amount of time the drug remains in a person’s system depends on significant personal variables, including individual rate of metabolism, gender, size, percentage of body fat, and how often and how much of the drug is typically used.

There are numerous research studies looking at the breakdown of the metabolites of 2-CE; however, formal guidelines regarding the detectability of this drug are not readily available.

    Based on some of the research studies, the following can be concluded:

  • The drug has a slow onset of action.
  • The drug has a fairly long half-life for its class. The estimated average half-life of the drug is around four hours but may be longer in some individuals, depending on the amount taken and other variables.
  • Because of its fairly long half-life, it may be eliminated relatively slowly compared to similar drugs.

The following are estimates based on research studies, information about very similar drugs, and other data.

    It can be estimated that 2-CE is:

  • Detectable in urine for up to 2-5 days
  • Detectable in blood for up to 24 hours
  • Detectable in saliva for up to 2-5 days
  • Detectable in hair for up to 90 days

Again, these are general estimates based on numerous research studies and the detectability of similar drugs.